KIF5C

kinesin family member 5C

Ensembl:
ENSG00000276734, ENSG00000168280
UniProt:
O60282
OMIM:
604593
Synonyms:
NKHC2

Cilia effects upon perturbation of KIF5C

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.58) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased lymphocyte cell number, increased circulating total protein level, increased eosinophil cell number

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth
  • Cilia length regulation

Function

LoF of KIF5C did not change cilia length and ciliation (PMID: 29445114).

Model organism evidence

C. elegans (1 reference)

Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli.

PMIDs: 33460640