KIF5C

kinesin family member 5C

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000276734
UniProt:
O60282
OMIM:
604593
Synonyms:
NKHC2

Cilia effects upon perturbation of KIF5C

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.58) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased lymphocyte cell number, increased circulating total protein level, increased eosinophil cell number

Subcellular localization

flagella

References: PMID:29445114

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth
  • Cilia length regulation

Function

LoF of KIF5C did not change cilia length and ciliation (PMID: 29445114).