KIF6
kinesin family member 6
- Ensembl:
- ENSG00000164627
- UniProt:
- Q6ZMV9
- OMIM:
- 613919
- Synonyms:
- C6ORF102, DJ1043E3.1, DJ137F1.4, DJ188D3.1, DKFZP451I2418
Cilia effects upon perturbation of KIF6
- Cilia number / % ciliated:
- Unknown
- Loss-of-function effect:
- Unknown
- Overexpression effect:
- Unknown
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- small heart, decreased brain size
- Mouse ciliopathy phenotype:
- abnormal uterus morphology, abnormal brain morphology, female infertility, small testis, male infertility, abnormal testis morphology, hydrocephaly, hydrometra, abnormal heart morphology
Subcellular localization
cilia, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Metabolism
Function
Mediator of ciliogenesis and normal cilia beating in ependmal cells in vertebrates. Mutations are reported to be associated with neurological abnormalities in humans (30475797).
Model organism evidence
Mus musculus (2 references)
Here, we show that Kif6 is a slow processive motor (12.2±2.0 nm/s) on microtubules in vitro and localizes to both the apical cytoplasm and the axoneme in ependymal cells, although it does not display processive movement in vivo.
We find that loss of Kif6 function caused decreased ependymal cilia motility and subsequently decreased fluid flow on the surface of brain ventricular walls.