KIF6

kinesin family member 6

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000164627
UniProt:: Q6ZMV9
OMIM:: 613919
Synonyms:: C6ORF102, DJ1043E3.1, DJ137F1.4, DJ188D3.1, DKFZP451I2418, MGC33317

Cilia effects upon perturbation of KIF6

Cilia number / % ciliated:: Unknown
Loss-of-function effect:: Unknown
Overexpression effect:: Unknown

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: small heart, decreased brain size

Subcellular localization

cilia, nucleus, basal body

References: PMID:41005307, PMID:25139857, PMID:30475797

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism

Function

Mediator of ciliogenesis and normal cilia beating in ependmal cells in vertebrates. Mutations are reported to be associated with neurological abnormalities in humans (30475797).

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