KIF9

kinesin family member 9

Ensembl:
ENSG00000088727
UniProt:
Q9HAQ2
OMIM:
607910
Synonyms:
MGC104186

Cilia effects upon perturbation of KIF9

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Shorter cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
small spleen, small liver, developmental dysplasia, abnormal skin morphology
Mouse ciliopathy phenotype:
abnormal liver morphology, male infertility

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Kif9 is necessary for ciliary motility and the proper distal localization of not only central pair proteins, but also radial spokes and dynein arms (35531639). Kif9 is integral for ciliary beating and is necessary for proper axonemal distal end integrity.(PMID: 35531639) KIF9 loss causes centriolar satellite aggregation near centrosome, leading to cilia length defects. Alters levels of TALPID3, CEP131, CEP170, and CEP290. Disrupts cilia length without necessarily affecting ciliation frequency.

Model organism evidence

Mus musculus (4 references)

The highly conserved kinesin family member 9 (KIF9) localizes to the central microtubule pair in the flagella of Chlamydomonas cells.

Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes.

PMIDs: 36686457, 35531639, 34526446, 32072696

Xenopus (1 reference)

Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes.

PMIDs: 35531639