KIFAP3

kinesin associated protein 3

Ensembl:
ENSG00000075945
UniProt:
Q92845
OMIM:
601836
Synonyms:
FLA3, KAP-1, KAP3, SMAP

Cilia effects upon perturbation of KIFAP3

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.72) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-4.59) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.51, ciliated=18.4%) PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, impaired glucose tolerance

Subcellular localization

basal body, centrosome, cytosol, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transition zone

Function

KIFAP3 has localized in basal body.

Model organism evidence

Mus musculus (1 reference)

Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for ciliogenesis.

PMIDs: 38405607