KIFC1

kinesin family member C1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000237649
UniProt:: Q9BW19
OMIM:: 603763
Synonyms:: HSET, KNSL2

Cilia effects upon perturbation of KIFC1

Cilia number / % ciliated:: Unknown
Loss-of-function effect:: Unknown
Overexpression effect:: Unknown

Ciliogenesis screen results (3 screens)

Kim2016: No effect
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.59, ciliated=17.8%) PMID:26595381

Subcellular localization

basal body, cilia, microtubules, nucleus

References: PMID:41005307, PMID:29042452

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Ciliary membrane

Function

Required for ciliary membrane protein transport and serum starvation–induced ciliogenesis. Role in the Golgi transport of membrane proteins from the Golgi complex to the primary cilium and in the recruitment of ciliogenesis regulators and maintenance. Required for TTBK2 recruitment and CP110 removal from the distal end of the mother centriole to iniciate cilium assembly (29042452).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.