KISS1R

Cilia effects upon perturbation of KISS1R

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.89) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

absent ovary, abnormal ovary morphology, increased thymus weight, abnormal epididymis morphology, absent testes, absent semil vesicle, decreased heart weight, absent epididymis, aplasia, absent uterus, abnormal semil vesicle morphology, hypoplasia, decreased body weight, increased spleen weight, decreased bone mineral density, decreased locomotor activity, decreased lean body mass, increased total body fat amount, decreased bone mineral content, abnormal bone structure

Mouse ciliopathy phenotype:

small kidney, abnormal uterus morphology, abnormal testis morphology, male infertility, abnormal kidney morphology, decreased kidney weight, female infertility, increased circulating creatinine level

Subcellular localization

basal body, cilia

Functional category

• Ciliary assembly/disassembly
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Ciliary receptor which plays a role in reproductive function. Cilia are required for proper Kiss1r-mediated sig ling on GnRH neurons

Model organism evidence