KIT

KIT proto-oncogene, receptor tyrosine kinase

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000157404
UniProt:: P10721
OMIM:: 164920
Synonyms:: C-KIT, CD117, PBT, SCFR

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.33) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:: renal cell carcinoma

Subcellular localization

plasma membrane

Functional category

Metabolism

Function

Involvement of C-Kit receptor tyrosine kinase in the maintenance of ciliary epithelial neural stem cells: interaction with notch signaling(A.V. Das). GLI3 and KIT mutations had a synergistic, tumorigenic effect on the onset of mastocytosis in a Greig cephalopolysyndactyly syndrome mouse model (PMID: 34424959).

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