KLB

klotho beta

Ensembl:
ENSG00000134962
UniProt:
Q86Z14
OMIM:
611135

Cilia effects upon perturbation of KLB

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=618, lfc=-0.68) PMID:30270045

Phenotypes

Mouse phenotype:
decreased grip strength, abnormal embryo size, preweaning lethality, incomplete penetrance, abnormal placenta size, abnormal placenta vasculature

Subcellular localization

flagella

Functional category

  • Signaling (Hedgehog, GPCRs, ion channels)

Function

KLB localized to flagella (25613900)