KLC1

kinesin light chain 1

Ensembl:: ENSG00000126214
UniProt:: Q07866
OMIM:: 600025
Synonyms:: HKLC1B, HKLC1G, HKLC1J, HKLC1N, HKLC1P

Cilia effects upon perturbation of KLC1

Cilia number / % ciliated:: No effect
Loss-of-function effect:: Longer cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)
Cilia length regulation

Function

Interacts with CCDC28B to regulate cilia length. Regulation the sub-cellular distribution of CCDC28B by loading CCDC28B onto KIF5B-based motors at the pericentriolar region (29445114).

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