KLC3

kinesin light chain 3

Ensembl:
ENSG00000104892
UniProt:
Q6P597
OMIM:
601334
Synonyms:
KLC2L, KLCT, KNS2B

Cilia effects upon perturbation of KLC3

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased circulating alkaline phosphatase level

Subcellular localization

basal body, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

CILK1 deficiency in a mouse model leads to polycystic kidney disease (PKD) with abnormal ciliary trafficking and that kinesin light chain鈥

Model organism evidence

Mus musculus (1 reference)

Immunocytochemistry and co-IP were used to examine the effect of KLC3 on ciliary trafficking of the IFT-B complex and EGFR.

PMIDs: 35961787