KLC3

kinesin light chain 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000104892
UniProt:: Q6P597
OMIM:: 601334
Synonyms:: KLC2L, KLCT, KNS2B

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased circulating alkaline phosphatase level

Subcellular localization

basal body, microtubules

References: PMID:35961787

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

KLC3 (kinesin light chain 3) interacts with CILK1 at the ciliary base and is increased in cyst-lining cells of CILK1-deficient mouse kidneys. KLC3 overexpression promotes ciliary recruitment of IFT-B and EGFR, and reducing KLC3 rescues the ciliary defects and slows cyst progression caused by CILK1 deficiency (PMID 35961787).

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