KLF2

KLF transcription factor 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000127528
OMIM:: 602016
Synonyms:: LKLF

Subcellular localization

Nucleoplasm, Cytosol

Function

In this study we demonstrated that blood flow change could be perceived and transmitted in a primary cilia dependent manner to control the hemodynamic responsive klf2 gene expression and subsequent activation of Notch signaling in the endocardium. First we showed that both homologues of human gene KLF2 in zebrafish, klf2a and klf2b, could respond to hemodynamic alteration and both were required for Notch signaling activation and heart regeneration(32249387).

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