KLF4

KLF transcription factor 4

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000136826
UniProt:
O43474
OMIM:
602253
Synonyms:
EZF, GKLF

Cilia effects upon perturbation of KLF4

Overexpression effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.60) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased grip strength

Subcellular localization

nucleus

References: PMID:30193838

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

KLF4 plays important roles for maintaining osteoblasts in an immature state by repressing basal activation of the Hedgehog signaling ( 30193838). KLF4 supports the formation and maintenance of cilia in cultured osteoblasts, however, the length of the cilia observed in KLF4-induced cells were significantly shorter compared to control cells. (30193838)