KLF4

KLF transcription factor 4

Ensembl:
ENSG00000136826
UniProt:
O43474
OMIM:
602253
Synonyms:
EZF, GKLF

Cilia effects upon perturbation of KLF4

Overexpression effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.60) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased grip strength

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

KLF4 plays important roles for maintaining osteoblasts in an immature state by repressing basal activation of the Hedgehog sig ling ( 30193838). KLF4 supports the formation and maintenance of cilia in cultured osteoblasts, however, the length of the cilia observed in KLF4-induced cells were significantly shorter compared to control cells. (30193838)

Model organism evidence

Mus musculus (2 references)

Here, we identify that primary cilia and blood flow in mouse embryos regulate early valve development in vivo by regionally controlling endothelial-to-mesenchymal transition (EndoMT) through the modulation of Krüppel-like factor 4 (Klf4) in the endocardial cushions.

Here, we identify a role for primary cilia in vivo in the spatial regulation of cushion formation, the first stage of valve development, by regionally controlling endothelial to mesenchymal transition (EndoMT) via modulation of Kruppel-like Factor 4 (Klf4) .

PMIDs: 40858839, 38798559