KLHL10

kelch like family member 10

Ensembl:: ENSG00000161594
UniProt:: Q6JEL2
OMIM:: 608778
Synonyms:: FLJ32662

Cilia effects upon perturbation of KLHL10

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse ciliopathy phenotype:: male infertility

Subcellular localization

flagella

Functional category

Reproduction & sperm

Function

KLHL10 has localized in flagella.

Model organism evidence

Mus musculus (1 reference)

Tdrd6 is involved in the formation of the chromatoid body, Tnp2 contributes to the formation of sperm heads, Tekt2 is required for the formation of ciliary and flagellar microtubules, and Klhl10 plays a key role in the elongated sperm differentiation.

PMIDs: 29731491

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