KPNA2

karyopherin subunit alpha 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000198290
UniProt:: P52292
OMIM:: 600685
Synonyms:: importin alpha 1, IPOA1, RCH1, SRP1

Cilia effects upon perturbation of KPNA2

Cilia number / % ciliated:: Decrease
Loss-of-function effect:: Decrease

Ciliogenesis screen results (1 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.59) PMID:26167766

Subcellular localization

cilia, cytosol, nucleus

References: PMID:41017282

Functional category

Ciliary assembly/disassembly

Function

Importin alpha (KPNA2) has conserved localization in human epithelial primary cilia and Xenopus laevis epidermal multiciliated cells. Regulates ciliogenesis and cilia length maintenance in a palmitoylation-dependent manner. Key ciliary proteins CEP164 and ARL13B are candidate binding partners via their NLS. Disruption of importin alpha palmitoylation causes nephrogenesis defects in Xenopus (PMID:41017282). Importin alpha (KPNA2) localizes to human epithelial primary cilia and Xenopus multiciliated cells. Regulates ciliogenesis and cilia length via palmitoylation. Disruption causes nephrogenesis defects in Xenopus.

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