KRT34

keratin 34

Ensembl:: ENSG00000292033, ENSG00000262045, ENSG00000131737
UniProt:: O76011
OMIM:: 602763
Synonyms:: HA-4, KRTHA4

Cilia effects upon perturbation of KRT34

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal lymph node morphology, enlarged spleen, abnormal thymus morphology, cornea opacity, enlarged thymus, enlarged lymph nodes, decreased locomotor activity, increased circulating hdl cholesterol level, abnormal spleen morphology
Mouse ciliopathy phenotype:: abnormal heart morphology, enlarged heart, increased kidney weight

Ciliopathy associations

Primary Ciliary Dyskinesia

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly

Function

Regarding protein KRT34, staining was observed in the cytoplasm and the base of the cilia (31835165).

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