KRT34

keratin 34

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000292033
UniProt:: O76011
OMIM:: 602763
Synonyms:: HA-4, KRTHA4

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal lymph node morphology, enlarged spleen, abnormal thymus morphology, cornea opacity, enlarged thymus, enlarged lymph nodes, decreased locomotor activity, increased circulating hdl cholesterol level, abnormal spleen morphology

Ciliopathy associations

Primary Ciliary Dyskinesia

References: PMID:31835165

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly

Function

Regarding protein KRT34, staining was observed in the cytoplasm and the base of the cilia (31835165).

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