KRT5

keratin 5

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000186081
UniProt:: P13647
OMIM:: 148040
Synonyms:: CK-5, EBS2, KRT5A

Ciliogenesis screen results (5 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.30) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=522, lfc=-0.55) PMID:30270045

Phenotypes

Mouse phenotype:: abnormal lymph node morphology, preweaning lethality, incomplete penetrance, preweaning lethality, complete penetrance

Subcellular localization

cytosol, nucleus

References: PMID:28004801

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

The loss of ciliated cells was compensated by the cells which contained the KRT5 basal cell marker but were not yet differentiated into ciliated cells ( 28004801).

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