KRT5

keratin 5

Ensembl:
ENSG00000186081
UniProt:
P13647
OMIM:
148040
Synonyms:
CK-5, EBS2, KRT5A

Cilia effects upon perturbation of KRT5

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.30) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=522, lfc=-0.55) PMID:30270045

Phenotypes

Mouse phenotype:
abnormal lymph node morphology, preweaning lethality, incomplete penetrance, preweaning lethality, complete penetrance

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

The loss of ciliated cells was compensated by the cells which contained the KRT5 basal cell marker but were not yet differentiated into ciliated cells ( 28004801).

Model organism evidence

Mus musculus (1 reference)

In this model, the reduced size of basal cell primary cilia was associated with impaired Hedgehog signaling and the loss of KRT5, KRT14, and P63 basal cell markers.

PMIDs: 36261680