LARP6
La ribonucleoprotein 6, translational regulator
- Ensembl:
- ENSG00000166173
- UniProt:
- Q9BRS8
- OMIM:
- 611300
- Synonyms:
- ACHERON, FLJ11196
Cilia effects upon perturbation of LARP6
- Cilia number / % ciliated:
- Decreased cilia number
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.55) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- increased circulating alkaline phosphatase level, increased circulating triglyceride level, abnormal eye morphology, abnormal skin morphology, abnormal semil vesicle morphology
Subcellular localization
cilia associated gene, nucleus
Functional category
- Ciliary assembly/disassembly
Function
The binding of LARP6 and D AF6 in dynein axonemal particles regulates highly expressed α-tubulin protein near the apical side of Xenopus MCCs during ciliogenesis. Knockdown of LARP6 in Xenopus embryos resulted in neural tube closure defects that were coincident with the absence of cilia. The absence of cilia at the epidermis was also observed in LARP6 morphants, and this defect was due to the absence of basal bodies at the apical cell surface. (28344782)
Model organism evidence
The binding of LARP6 and DNAAF6 in biomolecular condensates influences ciliogenesis of multiciliated cells.
To identify the molecular mechanism underlying ciliogenesis regulated by LARP6, we tested the expression level of cilia-related genes, which play important roles in ciliogenesis, by RT-PCR or whole mount in situ hybridization (WISH).
La-related protein 6 (Larp6) is a conserved RNA-binding protein found across eukaryotes that has been suggested to regulate collagen biogenesis, muscle development, ciliogenesis, and various aspects of cell proliferation and migration.
PMIDs: 32054660