LATS1

large tumor suppressor kinase 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000131023
UniProt:: O95835
OMIM:: 603473
Synonyms:: WARTS

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.57) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased grip strength, decreased locomotor activity, increased grip strength, decreased prepulse inhibition, decreased hemoglobin content

Subcellular localization

basal body, cytosol

References: PMID:26530630

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

In wild-type (Lats1+/+) MEFs, Lats1 colocalized with γ-tubulin, a component of the pericentriolar material (PCM) that accumulated substantially at the basal bodys (corresponding to mature basal bodys) during late G2 phase, metaphase and a /telophase (26530630).

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