LATS2

large tumor suppressor kinase 2

Ensembl:
ENSG00000150457
UniProt:
Q9NRM7
OMIM:
604861

Cilia effects upon perturbation of LATS2

Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.31, ciliated=19.9%) PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

S83 of Lats2 is a phosphorylation target of Aurora-A and this phosphorylation plays a role of the centrosomal localization of Lats2 (15147269). LATS1/2 is dispensable for serum starvation-mediated ciliogenesis. (25849865)

Model organism evidence

Mus musculus (1 reference)

Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS).

PMIDs: 30814930