LATS2

large tumor suppressor kinase 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000150457
UniProt:: Q9NRM7
OMIM:: 604861

Cilia effects upon perturbation of LATS2

Loss-of-function effect:: No effect

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.31, ciliated=19.9%) PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

References: PMID:15147269, PMID:25849865

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

S83 of Lats2 is a phosphorylation target of Aurora-A and this phosphorylation plays a role of the centrosomal localization of Lats2 (15147269). LATS1/2 is dispensable for serum starvation-mediated ciliogenesis. (25849865)

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