LCA5L

lebercilin LCA5 like

Ensembl:: ENSG00000157578
UniProt:: O95447
Synonyms:: C21ORF13, MGC33295

Cilia effects upon perturbation of LCA5L

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: thrombocytopenia, decreased hematocrit, decreased hemoglobin content, increased total reti thickness, increased circulating cholesterol level, decreased erythrocyte cell number
Mouse ciliopathy phenotype:: male infertility, increased circulating bilirubin level

Subcellular localization

basal body, flagella

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

LCA5L has localized in basal body,flagella.

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