LCTL

lactase like

Ensembl:
ENSG00000188501
UniProt:
Q6UWM7
OMIM:
617060
Synonyms:
FLJ33279, KLG, KLPH

Cilia effects upon perturbation of LCTL

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.70) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation ( 29425878).

Model organism evidence

Mus musculus (1 reference)

RNA-seq profiles for KO and WT littermates confirmed the absence of KLPH mRNA in KO lens and also showed complete absence of transcripts for Clic5, a protein associated with cilium/basal body related auditory defec

PMIDs: 29425878