LCTL

lactase like

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000188501
UniProt:: Q6UWM7
OMIM:: 617060
Synonyms:: FLJ33279, KLG, KLPH

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.70) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:29425878

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation ( 29425878).

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