LDLRAD1

low density lipoprotein receptor class A domain containing 1

Ensembl:
ENSG00000203985
UniProt:
Q5T700

Cilia effects upon perturbation of LDLRAD1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.32) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased circulating alkaline phosphatase level, decreased circulating total protein level, abnormal skin coloration, decreased circulating serum albumin level
Mouse ciliopathy phenotype:
decreased circulating calcium level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

LDLRAD1 has localized in cilia.