LEFTY1

left-right determination factor 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000243709
UniProt:: O75610
OMIM:: 603037
Synonyms:: LEFTB, LEFTYB

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.11) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, increased circulating potassium level, increased total body fat amount, abnormal gait

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:19481538

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Cardiac & muscle development

Function

Fgf4 was essential for the expression of lefty1, which is necessary for the asymmetric expression of southpaw and pitx2 in the lateral plate mesoderm, in the posterior notochord, and the expression of lefty2 and lefty1 in the left cardiac field ( 19481538).

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