LEFTY1
left-right determination factor 1
- Ensembl:
- ENSG00000243709
- UniProt:
- O75610
- OMIM:
- 603037
- Synonyms:
- LEFTB, LEFTYB
Cilia effects upon perturbation of LEFTY1
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.11) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- preweaning lethality, complete penetrance, increased circulating potassium level, increased total body fat amount, abnormal gait
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
Function
Fgf4 was essential for the expression of lefty1, which is necessary for the asymmetric expression of southpaw and pitx2 in the lateral plate mesoderm, in the posterior notochord, and the expression of lefty2 and lefty1 in the left cardiac field ( 19481538).
Model organism evidence
Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly, with known roles in left-right (LR) patterning in zebrafish and links to human ciliopathies.
It plays a known role in Left-Right (LR) patterning in zebrafish and is linked to human ciliopathies.
Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly, with known roles in left-right (LR) patterning in zebrafish and links to human ciliopathies.
It plays a known role in Left-Right (LR) patterning in zebrafish and is linked to human ciliopathies.