LEFTY2

left-right determination factor 2

Ensembl:
ENSG00000143768
UniProt:
O00292
OMIM:
601877
Synonyms:
EBAF, LEFTA, LEFTYA, TGFB4

Cilia effects upon perturbation of LEFTY2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.27) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Randomized expression of asymmetric genes, such as Nodal, Lefty2, and Pitx2, in the LPM of Pierce1-null embryos, indicating that PIERCE1 functions at the initial step of LR specification ( 27305836).

Model organism evidence

Mus musculus (3 references)

Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly, with known roles in left-right (LR) patterning in zebrafish and links to human ciliopathies.

It plays a known role in Left-Right (LR) patterning in zebrafish and is linked to human ciliopathies.

PMIDs: 40955177, 40463022, 28182636

Danio rerio (3 references)

Cfap298 is a highly conserved gene required for ciliary motility and dynein arm assembly, with known roles in left-right (LR) patterning in zebrafish and links to human ciliopathies.

It plays a known role in Left-Right (LR) patterning in zebrafish and is linked to human ciliopathies.

PMIDs: 40955177, 40463022, 30317609