LEFTY2

left-right determination factor 2

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000143768
UniProt:
O00292
OMIM:
601877
Synonyms:
EBAF, LEFTA, LEFTYA, TGFB4

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.27) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:27305836

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Randomized expression of asymmetric genes, such as Nodal, Lefty2, and Pitx2, in the LPM of Pierce1-null embryos, indicating that PIERCE1 functions at the initial step of LR specification ( 27305836).