LEPROT

leptin receptor overlapping transcript

Ensembl:
ENSG00000213625
UniProt:
O15243
OMIM:
613461
Synonyms:
FLJ90360, OB-RGRP, OBRGRP, VPS55

Cilia effects upon perturbation of LEPROT

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased bone mineral content, decreased total body fat amount, increased food intake, increased lean body mass, increased red blood cell distribution width

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Immunocytochemistry for AC3 or the basal body marker γ-tubulin in LEPR-EGFP–expressing cells demonstrated that LEPR-EGFP localized to the γ-tubulin–stained basal body , which indicates that the leptin sig ling machinery is a tomically linked to cilia–basal body complexes (24667636).