LGALS3BP

galectin 3 binding protein

Ensembl:: ENSG00000108679
UniProt:: Q08380
OMIM:: 600626
Synonyms:: 90K, BTBD17B, CYCAP, GP90, M2BP

Cilia effects upon perturbation of LGALS3BP

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.54) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

The central component of microtubule nucleation complex is the evolutio rily highly conserved 纬-tubulin (TUBG1)(11005013) that forms together with TUBGCP2 and TUBGCP3 the 纬-tubulin small complex (纬-TuSC)(9566967). Although higher levels of LGALS3BP expression lead to the dispersion of PCM, depletion results in the generation of multiple centriolar structures. The PCM hypertrophy- and accumulation of centriolar structure-phenotypes correlate directly with centrosome morphology aberrations in cancer cells and patient tissues with deregulated levels of LGALS3BP(23443559).

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