LGR5

leucine rich repeat containing G protein-coupled receptor 5

Ensembl:
ENSG00000139292
UniProt:
O75473
OMIM:
606667
Synonyms:
FEX, GPR49, GPR67, HG38

Cilia effects upon perturbation of LGR5

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.81) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased grip strength, increased cd11b-high dendritic cell number, no spontaneous movement, cleft palate, increased cd8-positive, cd25-positive alpha-beta t cell number, preweaning lethality, complete penetrance

Subcellular localization

basal body, cilia, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

LGR5 has localized in basal body ,transition zone.