LHCGR

luteinizing hormone/choriogonadotropin receptor

Ensembl:: ENSG00000138039
UniProt:: P22888
OMIM:: 152790
Synonyms:: HHG, LCGR, LGR2, LHR, ULG5

Cilia effects upon perturbation of LHCGR

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: small stomach, small thymus, small lung, small liver, increased lymphocyte cell number, thrombocytopenia, increased leukocyte cell number, decreased mean corpuscular volume, small heart, small spleen, decreased brain size
Human ciliopathy phenotype:: infertility

Subcellular localization

basal body, lysosomes

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

LHCGR localized to basal body (25613900) The percentage of ciliated epithelial cells and their cilia height is decreased in Lhcgr mutant epididymal epithelium.

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