LIG1

DNA ligase 1

Ensembl:
ENSG00000105486
UniProt:
P18858
OMIM:
126391
Synonyms:
HLIG1, LIGI

Cilia effects upon perturbation of LIG1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.47) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Viral interactions
  • Transcription regulation

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378).