LIG1

DNA ligase 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000105486
UniProt:: P18858
OMIM:: 126391
Synonyms:: HLIG1, LIGI

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.47) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:23516378, PMID:24917610

Functional category

Ciliary assembly/disassembly
Viral interactions
Transcription regulation

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378). DNA ligase 1 was detected in the isolated flagella of Chlamydomonas reinhardtii in a global phosphoproteome study (Wang et al., 2014, Mol Cell Proteomics, PMID 24917610). This is weak evidence: LIG1 is a ubiquitous DNA replication and repair enzyme.

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