LIMA1

LIM domain and actin binding 1

Ensembl:: ENSG00000050405
UniProt:: Q9UHB6
OMIM:: 608364
Synonyms:: EPLIN

Cilia effects upon perturbation of LIMA1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased thigmotaxis, preweaning lethality, incomplete penetrance

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Also known as EPLIN. Modulates actin stability to restrict primary cilia formation. Knockdown increases the levels of MyosinVa at the centrosome and primary cilia formation (32496561)

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