LPAR1

lysophosphatidic acid receptor 1

Ensembl:
ENSG00000198121
UniProt:
Q92633
OMIM:
602282
Synonyms:
EDG-2, EDG2, GPCR26, LPA1, MREC1.3

Cilia effects upon perturbation of LPAR1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.46) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.05) PMID:41160700

Phenotypes

Mouse phenotype:
increased fasting circulating glucose level, preweaning lethality, complete penetrance, improved glucose tolerance
Mouse ciliopathy phenotype:
cataract

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

LPA-LPAR1-driven mitogenic sig ling was restricted in cells with primary cilium due to compartmentalization of LPAR1 and its downstream effectors, G伪12 and G伪q, in cilia and in cytoplasm, respectively. LPAR1 was redistributed to the plasma membrane upon loss of primary cilium, thus e bling its binding to G伪12 and G伪q, and therefore suggesting that redistribution of LPAR1 is a key mechanism driving proliferation in a cilia-dependent manner(29321663).

Model organism evidence

Mus musculus (1 reference)

Genetic inactivation and pharmacological inhibition of LPA receptor 1 (LPAR1) abrogate cilia disassembly triggered by serum.

PMIDs: 33510165

Danio rerio (1 reference)

Knockdown of either Atx or Lpar3 impaired calcium fluxes in DFCs during mid-epiboly stage and compromised DFC cohesive migration, KV formation and ciliogenesis.

PMIDs: 23095890