LPAR3

lysophosphatidic acid receptor 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000171517
UniProt:
Q9UBY5
OMIM:
605106
Synonyms:
EDG-7, EDG7, HOFNH30, LP-A3, LPA3, RP4-678I3

Cilia effects upon perturbation of LPAR3

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.43) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:41005307, PMID:33510165, PMID:34831200

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

LPAR3 has localized in primary cilia. Lpar1 is critical for proper ciliogenesis, VZ/SVZ generation, and neocortex formation … Deletion of Lpar1 in mice causes abnormally elongated cilia and decreased proliferation in neural progenitor cells. (33510165) Knockdown of LPAR1 blocked the fetal bovine serum (FBS)- or LPA-induced cilia disassembly in RPE-1 cells. (33510165) Depletion of LPA or LPAR1 results in slower cilia disassembly and longer cilia. (34831200)