LPAR3

lysophosphatidic acid receptor 3

Ensembl:
ENSG00000171517
UniProt:
Q9UBY5
OMIM:
605106
Synonyms:
EDG-7, EDG7, HOFNH30, LP-A3, LPA3

Cilia effects upon perturbation of LPAR3

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.43) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

LPAR3 has localized in primary cilia. Lpar1 is critical for proper ciliogenesis, VZ/SVZ generation, and neocortex formation … Deletion of Lpar1 in mice causes abnormally elongated cilia and decreased proliferation in neural progenitor cells. (33510165) Knockdown of LPAR1 blocked the fetal bovine serum (FBS)- or LPA-induced cilia disassembly in RPE-1 cells. (33510165) Depletion of LPA or LPAR1 results in slower cilia disassembly and longer cilia. (34831200)

Model organism evidence

Danio rerio (1 reference)

Knockdown of either Atx or Lpar3 impaired calcium fluxes in DFCs during mid-epiboly stage and compromised DFC cohesive migration, KV formation and ciliogenesis.

PMIDs: 23095890