LRRC23

leucine rich repeat containing 23

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000010626
UniProt:: Q53EV4
OMIM:: 620708
Synonyms:: B7, LRPB7

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.10) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

References: PMID:37804054, PMID:38091523, PMID:34585727

Subcellular localization

cilia

References: PMID:41410385, PMID:42010243, PMID:29475374, PMID:39743588

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

Radial spoke protein with function in ciliary motility and motile cilia formation. Mutations in Lrrc23 result in ciliary motility defects specifically in the cilia of the otic vesicle (29475374). Identified by cryo-EM as a component of radial spoke 3 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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