LRRC23

leucine rich repeat containing 23

Ensembl:
ENSG00000010626
UniProt:
Q53EV4
OMIM:
620708
Synonyms:
B7, LRPB7

Cilia effects upon perturbation of LRRC23

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.10) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse ciliopathy phenotype:
increased circulating creatinine level, male infertility

Ciliopathy associations

  • Male Infertility

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Radial spoke protein with function in ciliary motility and motile cilia formation. Mutations in Lrrc23 result in ciliary motility defects specifically in the cilia of the otic vesicle (29475374).

Model organism evidence

Mus musculus (1 reference)

We found that LRRC23 localizes to the RS complex within murine sperm flagella and interacts with RSPH3A and RSPH3B.

PMIDs: 34585727

Danio rerio (1 reference)

Radial spokes are structurally conserved, macromolecular complexes that are essential for the motility of 9 + 2 motile cilia.

PMIDs: 29475374