LRRC34

leucine rich repeat containing 34

Ensembl:
ENSG00000171757
UniProt:
Q8IZ02
OMIM:
619037
Synonyms:
MGC27085

Cilia effects upon perturbation of LRRC34

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=5.33) PMID:20393562

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • T cell biology

Function

Mutated in Joubert syndrome. Localized along the ciliary shaft in controls but only at ciliary base in LRRC34-/- patient cells, which displayed reduced ciliogenesis potential and muted response of SHH sig ling to SAG compared with controls (32055034)