LRRC51

leucine rich repeat containing 51

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000184154

Phenotypes

Mouse phenotype:: abnormal retina morphology, abnormal retina blood vessel morphology

Subcellular localization

motile cilia, Microtubules

References: PMID:39743588

Functional category

Motors (dynein/kinesin)

Function

LRRC51 — A conserved motile cilia protein, part of the inner dynein arm (IDA) / I1 dynein-associated complex, essential for beating regulation(39743588). Identified by cryo-EM as a component of inner dynein arm f and the tether/tether head complex in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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