LRRC52

leucine rich repeat containing 52

Ensembl:
ENSG00000162763
UniProt:
Q8N7C0
OMIM:
615218
Synonyms:
FLJ25811

Cilia effects upon perturbation of LRRC52

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=865, lfc=0.45) PMID:30270045

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Slo3 and LRRC52 proteins localized in human sperm (24670955).

Model organism evidence

Mus musculus (1 reference)

Three different hKSper antagonists including clofilium, quinidine, and a polyclonal antibody of LRRC52 (LID1) were utilized to evaluate the effect of hKSper inhibition on sperm flagellar pHi.

PMIDs: 39498893

Xenopus (1 reference)

Recently, we reported that VSP is activated and generates polarized PtdIns(4,5)P2 distribution in sperm flagellum.

PMIDs: 32564653