LRRCC1

leucine rich repeat and coiled-coil centrosomal protein 1

Ensembl:: ENSG00000133739
UniProt:: Q9C099
OMIM:: 617791
Synonyms:: CLERC, KIAA1764, VFL1

Cilia effects upon perturbation of LRRCC1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.15) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased erythrocyte cell number
Mouse ciliopathy phenotype:: abnormal brain morphology, hydrocephaly, male infertility

Subcellular localization

basal body, centrosome, nucleus

Functional category

Ciliary assembly/disassembly

Function

The depletion of LRRCC1 in human cells induced defects in basal body structure, ciliary assembly, and ciliary sig ling, supporting that LRRCC1 cooperates with C2CD3 to organizing the distal region of basal bodys(35319462).

Model organism evidence

Xenopus (1 reference)

Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function.

PMIDs: 35067717

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