LUZP1

leucine zipper protein 1

Ensembl:
ENSG00000169641
UniProt:
Q86V48
OMIM:
601422
Synonyms:
LUZP

Cilia effects upon perturbation of LUZP1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Townes-Brocks Syndrome

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cardiac & muscle development

Function

Localizes to both actin filaments and the centrosome/basal body. Is an actin-stabilizing protein that regulates actin dy mics, at least in part, by mobilizing ARP2 to the centrosomes. Interacts with known ciliogenesis and cilia-length regulators. Depleting LUZP1 or its interacting protein, EPLIN, increases the levels of MyosinVa at the centrosome and primary cilia formation.LUZP1- or EPLIN-silenced cells had significantly longer primary cilia than control cells (32496561).

Model organism evidence

Mus musculus (2 references)

Concordantly, LUZP1 is an actin and microtubule-associated protein, which localizes to the centrosome, the basal body of primary cilia, the midbody, actin filaments and cellular junctions.

LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis and actin filament bundling.

PMIDs: 35738212, 33869174