LUZP1

leucine zipper protein 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000169641
UniProt:: Q86V48
OMIM:: 601422
Synonyms:: LUZP

Cilia effects upon perturbation of LUZP1

Cilia number / % ciliated:: Incrased cilia number
Loss-of-function effect:: Longer cilia
Overexpression effect:: Unknown

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

References: PMID:32496561

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Cardiac & muscle development

Function

Localizes to both actin filaments and the centrosome/basal body. Is an actin-stabilizing protein that regulates actin dynamics, at least in part, by mobilizing ARP2 to the centrosomes. Interacts with known ciliogenesis and cilia-length regulators. Depleting LUZP1 or its interacting protein, EPLIN, increases the levels of MyosinVa at the centrosome and primary cilia formation.LUZP1- or EPLIN-silenced cells had significantly longer primary cilia than control cells (32496561).

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