MAGI2

membrane associated guanylate kinase, WW and PDZ domain containing 2

Ensembl:
ENSG00000187391
UniProt:
Q86UL8
OMIM:
606382
Synonyms:
ACVRIP1, AIP1, ARIP1, KIAA0705, MAGI-2

Cilia effects upon perturbation of MAGI2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.62) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Phenotypes

Mouse phenotype:
increased body weight

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

SANS-Magi2 complex mediates endocytosis and regulates aspects of ciliogenesis and/or mainte nce of primary cilia (24608321). Knock down of Magi2 diminished number of cells with a primary cilium. The few emerging primary cilia in shRNA Magi2-transfected … are shortened (0.73 µm …) compared with controls (1.28 µm …). (24608321)