MAL

Cilia effects upon perturbation of MAL

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.90) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• T cell biology

Function

MAL overexpression is associated with shortened or absent cilia, abnormal cilium and cyst development. MAL may facilitate the organisation of apical cargo into microdomains to facilitate their targeting and trafficking (22895261). Involved in the proper condensation of membranes at the ciliary base, required for efficient primary cilium extension (25967552). MAL accumulates at the ciliary base … Knockdown of MAL expression resulted in … a drastic reduction … the percentage of ciliated cells and the length of the cilia. MAL is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation. (25967552)