MANF

mesencephalic astrocyte derived neurotrophic factor

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000145050
UniProt:: P55145
OMIM:: 601916
Synonyms:: ARMET, ARP

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.57) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Human ciliopathy phenotype:: diabetes, deafness, developmental delay, and short stature syndrome

Subcellular localization

endoplasmic reticulum, nucleus

References: PMID:29959908

Functional category

Ciliary assembly/disassembly

Function

MANF can protect cilia of DA neurons at an early stage, suggested that MANF participated in the whole process of neuronal degeneration ( 29959908).

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