MANF

Cilia effects upon perturbation of MANF

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.57) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Human ciliopathy phenotype:

diabetes, deafness, developmental delay, and short stature syndrome

Subcellular localization

cilia associated gene, endoplasmic reticulum, nucleus

Functional category

• Ciliary assembly/disassembly

Function

MANF can protect cilia of DA neurons at an early stage, suggested that MANF participated in the whole process of neuro l degeneration ( 29959908).