MAP1LC3A

microtubule associated protein 1 light chain 3 alpha

Ensembl:
ENSG00000101460
UniProt:
Q9H492
OMIM:
601242
Synonyms:
ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3

Cilia effects upon perturbation of MAP1LC3A

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.96) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=841, lfc=0.65) PMID:30270045

Subcellular localization

autophagosomes, basal body, cilia, cytosol, flagella, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Also known as LC3. Interacts with OFD1 and removes it from the centriolar satellite to initiate primary cilium biogenesis (24343661)