MAP1LC3B

microtubule associated protein 1 light chain 3 beta

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000140941
UniProt:
Q9GZQ8
OMIM:
609604
Synonyms:
ATG8F

Cilia effects upon perturbation of MAP1LC3B

Loss-of-function effect:
Likely decreased

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, basal body

References: PMID:41005307, PMID:34917923, PMID:25906314, PMID:33136096

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MAP1LC3B has localized in primary cilia. Autophagic mechanism of LC3B in nucleus regulates ciliary differentiation and function. (34917923) Cilium length correlates with LC3B-II/-I ratio. (25906314) Map1lc3B–/– mice protected from cilia shortening under CS exposure. (33136096)