MAP1LC3B2
microtubule associated protein 1 light chain 3 beta 2
- Ensembl:
- ENSG00000258102
- UniProt:
- A6NCE7
- OMIM:
- 620673
- Synonyms:
- ATG8G
Cilia effects upon perturbation of MAP1LC3B2
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Protein processing & maturation
Function
MAP1LC3B2 has localized in ciliary tip, primary cilia.
Model organism evidence
Mus musculus (2 references)
Based on observations that increased morphological and biochemical indicators of autophagy correlate with cilia shortening in our models, we posited that autophagy might regulate cilia length in response to CS in the lung.
Exposure to CS reduced cilia length and induced autophagy in vivo and in differentiated mouse tracheal epithelial cells (MTECs).