MAP2K1

mitogen-activated protein kinase kinase 1

Ensembl:
ENSG00000169032
UniProt:
Q02750
OMIM:
176872
Synonyms:
MAPKK1, MEK1, MKK1, PRKMK1

Cilia effects upon perturbation of MAP2K1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MAP2K1 has localized in basal body.