MAP2K2

Cilia effects upon perturbation of MAP2K2

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.12) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.24) PMID:41160700

Phenotypes

Mouse phenotype:

abnormal gait, decreased body weight, increased mean corpuscular volume, hypoplasia

Subcellular localization

basal body, cytosol, nucleus, peroxisome

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Neurogenesis & migration
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)

Function

After PDGFR伪伪 activation, both Mek1/2-Erk1/2 and Akt pathways were activated by phosphorylation beginning at 3 min of PDGF-AA stimulation . The increased level of Mek1/2 (by c-Raf-dependent Mek1/2 phosphorylation on serines 217 and 221 in the activation loop to activate Erk1/2) preferentially localized along and at the base of the cilium (16243034).