MAP3K12
mitogen-activated protein kinase kinase kinase 12
- Ensembl:
- ENSG00000139625
- UniProt:
- Q12852
- OMIM:
- 600447
- Synonyms:
- DLK, MEKK12, MUK, ZPK, ZPKP1
Cilia effects upon perturbation of MAP3K12
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- preweaning lethality, complete penetrance, increased heart left ventricle size
- Mouse ciliopathy phenotype:
- increased circulating creatinine level
Subcellular localization
cilia, cytosol
Functional category
- Ciliary assembly/disassembly
Function
Multiple regulators constrain the abundance of Caenorhabditis elegans DLK-1 in ciliated sensory neurons(39854273).
Model organism evidence
C. elegans (3 references)
elegans for altered patterns of GFP-tagged DLK-1 expressed from the endogenous locus, we have recently uncovered a mechanism by which the abundance of DLK-1 is tightly regulated by intraflagellar transport in ciliated sensory neurons.
An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration.