MAP4K3

mitogen-activated protein kinase kinase kinase kinase 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000011566
UniProt:
Q8IVH8
OMIM:
604921
Synonyms:
GLK, MAPKKKK3, RAB8IPL1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:29378827

Functional category

  • Ciliary assembly/disassembly

Function

GCK-2 (a MAP4K3 homolog) largely colocalized with OSM-3 and KAP-1 (29378827)