MAP4K3

mitogen-activated protein kinase kinase kinase kinase 3

Ensembl:
ENSG00000011566
UniProt:
Q8IVH8
OMIM:
604921
Synonyms:
GLK, MAPKKKK3, RAB8IPL1

Cilia effects upon perturbation of MAP4K3

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

GCK-2 (a MAP4K3 homolog) largely colocalized with OSM-3 and KAP-1 (29378827)

Model organism evidence

C. elegans (1 reference)

Cilium Length and Intraflagellar Transport Regulation by Kinases PKG-1 and GCK-2 in Caenorhabditis elegans Sensory Neurons.

PMIDs: 29378827