MAP9

Cilia effects upon perturbation of MAP9

Loss-of-function effect:

Shorter cilia

Overexpression effect:

Longer cilia

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.12) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia, transition zone

References: PMID:41005307, PMID:27930654, PMID:33798428, PMID:24553125, PMID:28993665, PMID:37650070

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

MAP9, originally identified as a MT-binding protein stabilizing MT structure during both mitosis and interphase in human cell lines (16049101). MAP9 has a role in the formation and function of primary cilia, specific expression of the C. elegans MAP9 ortholog MAPH-9 in ciliated sensory neurons (27930654, 33798428), map9 depletion induced developmental abnormalities related to cilia-dependent signaling pathways in zebrafish (24553125), and MAP9 localized in the photoreceptor CC region of canine reti (28993665). MAP9 is prominently localized in the basal body of primary cilia and played an important role in maintaining the structure of ciliary microtubule axoneme(37650070).