MAPK1

mitogen-activated protein kinase 1

Ensembl:
ENSG00000100030
UniProt:
P28482
OMIM:
176948
Synonyms:
ERK, ERK2, MAPK2, P41MAPK, PRKM1

Cilia effects upon perturbation of MAPK1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Suppresses ciliogenesis

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance
Human ciliopathy phenotype:
Intellectual disability

Subcellular localization

autophagosomes, basal body, cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

ERK2. Downstream of TGFBR1 and 2, which phosphorylate ERK1/2 at base of cilium upon TGFB stimulation